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Only two families with Evans syndrome have been reported in the English medical literature. The sister died of sepsis after a chronic course with severe exacerbattions. With time, remissions were prolonged and paralleled an improvement in joint hypermobility. The brother's disease course was one of remission and exacerbation. He died of congestive heart failure at the age of 8 years. He was treated with steroids, intravenous immunoglobulin and colchiccine with a variable response. The 9 month old had a chronic course with exacerbations. Subsequently, a similar diagnosis was made in two siblings (a 3 year old boy and a 1 day old girl). The occurrence of autoimmune hemolytic anemia and immune thrombocytopenia in the absence of a known underlying cause led to the diagnosis of Evans syndrome in a 9 month old male. International Nuclear Information System (INIS)Īhmed, Fathelrahman E. Neonatal familial Evans syndrome associated with joint hypermobility and mitral valve regurgitation in three siblings in a Saudi Arab family This association constitutes a severe disease of difficult treatment. This report emphasizes how the hematology and coagulation abnormalities of preeclampsia could be added to those abnormalities observed in Evans' syndrome. The present paper describes two pregnant women with Evans syndrome associated to preeclampsia. This is more frequent in females throughout first half of the life and during pregnancy. Hernández-Salazar, E MartÃnez-Abundis, C E González-Ortiz, C MĮvans' syndrome is an unusual illness of autoimmune etiology, characterized by thrombocytopenia and hemolytic anemia.